A multifunctional toolkit for target-directed cancer therapy

TitleA multifunctional toolkit for target-directed cancer therapy
Publication TypeJournal Article
Year of Publication2019
AuthorsTerrazas, Montserrat, Sanchez Dani, Battistini Federica, Villegas Núria, Brun-Heath Isabelle, and Orozco Modesto
JournalChemical Communications
Volume55
Issue6
Pagination802 - 805
Date Published2019
ISBN Number1359-7345
Abstract

Here we present 2shRNA, a shRNA-based nanobinder, which can simultaneously attack two therapeutic targets involved in drug resistance pathways and can additionally bind accessory molecules such as cell targeting peptides or fluorophores. We create 2shRNAs designed to specifically kill HER2+ breast cancer cells in the absence of a transfecting agent.

URLhttp://dx.doi.org/10.1039/C8CC08823C
Short TitleChem. Commun.
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