Nucleic acids in modern molecular therapies: A realm of opportunities for strategic drug design

TitleNucleic acids in modern molecular therapies: A realm of opportunities for strategic drug design
Publication TypeJournal Article
Year of Publication2024
AuthorsGenna, Vito, Reyes-Fraile Laura, Iglesias-Fernández Javier, and Orozco Modesto
JournalCurrent Opinion in Structural Biology
Volume87
Pagination102838
Date Published08/2024
ISBN Number0959-440X
Abstract

RNA vaccines have made evident to society what was already known by the scientific community: nucleic acids will be the “drugs of the future.” By modifying the genome, interfering in transcription or translation, and by introducing new catalysts into the cell or by mimicking antibody effects, nucleic acids can generate therapeutic activities that are not accessible by any other therapeutic agents. There are, however, challenges that need to be solved in the next few years to make nucleic acids usable in a wide range of therapeutic scenarios. This review illustrates how simulation methods can help achieve this goal.

URLhttps://www.sciencedirect.com/science/article/pii/S0959440X24000654
Short TitleCurrent Opinion in Structural Biology
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